{"id":8977,"date":"2025-11-26T13:32:04","date_gmt":"2025-11-26T13:32:04","guid":{"rendered":"https:\/\/lumomat.fr\/?p=8977"},"modified":"2025-11-26T13:32:05","modified_gmt":"2025-11-26T13:32:05","slug":"thesis-defense-axel-riquet","status":"publish","type":"post","link":"https:\/\/lumomat.fr\/eng\/thesis-defense-axel-riquet\/","title":{"rendered":"Thesis Defense &#8211; Axel Riquet &#8211; Tuesday December 9th 2025: M\u00f6bius hexaphyrins: towards metallo-allosteric receptors with photoswitchable chirality"},"content":{"rendered":"\n<p>\ud83c\udf93 <strong>Thesis defense<\/strong> &#8211; Axel Riquet will defend her PhD thesis: m\u00f6bius hexaphyrins: towards metallo-allosteric receptors with photoswitchable chirality <br>\ud83d\udcc5 Tuesday December 9th 2025 at 13:30 at the Rennes Institute of Chemical Sciences &#8211; Beaulieu Campus &#8211; Salle 160<\/p>\n\n\n\n<figure class=\"wp-block-image aligncenter size-full is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"985\" height=\"631\" src=\"https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Axel-Riquel-Mignature-Web.webp\" alt=\"\" class=\"wp-image-8979\" style=\"width:465px;height:auto\" srcset=\"https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Axel-Riquel-Mignature-Web.webp 985w, https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Axel-Riquel-Mignature-Web-300x192.webp 300w, https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Axel-Riquel-Mignature-Web-768x492.webp 768w, https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Axel-Riquel-Mignature-Web-18x12.webp 18w\" sizes=\"(max-width: 985px) 100vw, 985px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>This thesis is supervised by Dr. St\u00e9phane Le Gac &#8211; ISRC \/ Universit\u00e9 de Rennes <br>Examining Committee : <br>\u2796 Dr. C\u00e9line Olivier &#8211; Institut des Sciences Mol\u00e9culaires de Bordeaux &#8211; Reviewer <br>\u2796 Prof. Alexandre Martinez &#8211; Institut des Sciences Mol\u00e9culaires de Marseille &#8211; Reviewer <br>\u2796 Dr. Laure Guy &#8211; \u00c9cole Normale Sup\u00e9rieure de Lyon &#8211; Examiner<\/p>\n\n\n\n<p>This thesis is supported by University of Rennes<\/p>\n\n\n\n<p>\ud83d\udcc4 [Abstract] Hexaphyrins are dynamic pyrrolic macrocycles which are able to adopt a M\u00f6bius ring conformation. This peculiar scaffold possesses an inherent topological helical chirality. This thesis focuses on the chirality induction and its modulation. To achieve this, several innovative strategies have been employed. Firstly, with the use of hexaphyrine bearing a chiral amine or carboxylic acid arm. The formation of zinc(II) complexes with exogeneous azo ligands allowed the obtention of impressive chirality inductions with d.e. up to &gt;95%. The chiroptical activity of these systems has been modulated thanks to the trans-&gt;cis photoisomerization of the azo ligand giving rise to the formation of the very first M\u00f6bius ring with photoswitchable chiroptical activity. Also, new hexaphyrins with a second chiral recognition site composed of a squaramid unit, overhanging the ring, have been developped. Chirality inductions by remote control have been obtained thanks to different processes such as recognition or protonation. The modulation of the arrangement of the two recognition sites by conformational changes induced by complexation has also been observed. The promising results of these two strategies lay the foundation for the formation of allosteric receptors with photoswitchable chirality.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\ud83c\udf93<strong> Soutenance de Th\u00e8se<\/strong> &#8211; Axel Riquel soutiendra sa th\u00e8se intitul\u00e9e : hexaphyrines de M\u00f6bius : vers des r\u00e9cepteurs m\u00e9tallo-allost\u00e9riques \u00e0 chiralit\u00e9 photo-commutable <br>\ud83d\udcc5 Mardi 9 D\u00e9cembre 2025 \u00e0 13h30 \u00e0 l\u2019Institut des Sciences Chimiques de Rennes &#8211; Campus de Beaulieu &#8211; Salle 160<\/p>\n\n\n\n<p>Cette th\u00e8se est dirig\u00e9e par Dr. St\u00e9phane Le Gac &#8211; ISRC \/ Universit\u00e9 de Rennes <br>Jury : <br>\u2796 Dr. C\u00e9line Olivier &#8211; Institut des Sciences Mol\u00e9culaires de Bordeaux &#8211; Rapporteur <br>\u2796 Prof. Alexandre Martinez &#8211; Institut des Sciences Mol\u00e9culaires de Marseille &#8211; Rapporteur <br>\u2796 Dr. Laure Guy &#8211; \u00c9cole Normale Sup\u00e9rieure de Lyon &#8211; Examinatrice<\/p>\n\n\n\n<p>Cette th\u00e8se est soutenue par l\u2019Universit\u00e9 de Rennes<\/p>\n","protected":false},"excerpt":{"rendered":"<p>\ud83c\udf93 Thesis defense &#8211; Axel Riquet will defend her PhD thesis: m\u00f6bius hexaphyrins: towards metallo-allosteric receptors with photoswitchable chirality \ud83d\udcc5 Tuesday December 9th 2025 at 13:30 at the Rennes Institute of Chemical Sciences &#8211; Beaulieu Campus &#8211; Salle 160 This thesis is supervised by Dr. St\u00e9phane Le Gac &#8211; ISRC \/ Universit\u00e9 de Rennes Examining [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":8979,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"ast-content-background-meta":{"desktop":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"tablet":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""},"mobile":{"background-color":"var(--ast-global-color-5)","background-image":"","background-repeat":"repeat","background-position":"center center","background-size":"auto","background-attachment":"scroll","background-type":"","background-media":"","overlay-type":"","overlay-color":"","overlay-opacity":"","overlay-gradient":""}},"footnotes":""},"categories":[1],"tags":[],"class_list":["post-8977","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-actualites"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - 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