{"id":8991,"date":"2025-12-03T09:00:00","date_gmt":"2025-12-03T09:00:00","guid":{"rendered":"https:\/\/lumomat.fr\/?p=8991"},"modified":"2025-12-03T08:48:28","modified_gmt":"2025-12-03T08:48:28","slug":"thesis-defense-teodora-lupoi-wednesday-december-10th-2025-development-of-nanostructured-platforms-for-electrochemical-sensors-for-the-detection-of-environmental-pharmaceutical-pol","status":"publish","type":"post","link":"https:\/\/lumomat.fr\/eng\/thesis-defense-teodora-lupoi-wednesday-december-10th-2025-development-of-nanostructured-platforms-for-electrochemical-sensors-for-the-detection-of-environmental-pharmaceutical-pol\/","title":{"rendered":"Thesis Defense \u2013 Teodora Lupoi \u2013 Wednesday December 10th 2025: Development of nanostructured platforms for electrochemical sensors for the detection of environmental pharmaceutical pollutants"},"content":{"rendered":"<p>\ud83c\udf93 <strong>Thesis Defense<\/strong> &#8211; Teodora Lupoi will defend her PhD thesis: development of nanostructured platforms for electrochemical sensors for the detection of environmental pharmaceutical pollutants <br>\ud83d\udcc5 Wednesday December 10th 2025 at 9:00 at the University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d in Cluj-Napoca \u2013 Romania<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<figure class=\"wp-block-image aligncenter size-large is-resized\"><img fetchpriority=\"high\" decoding=\"async\" width=\"820\" height=\"1024\" src=\"https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Soutenance-These-Teodora-Lupoi@72x-820x1024.webp\" alt=\"\" class=\"wp-image-8992\" style=\"width:480px;height:auto\" srcset=\"https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Soutenance-These-Teodora-Lupoi@72x-820x1024.webp 820w, https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Soutenance-These-Teodora-Lupoi@72x-240x300.webp 240w, https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Soutenance-These-Teodora-Lupoi@72x-768x959.webp 768w, https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Soutenance-These-Teodora-Lupoi@72x-10x12.webp 10w, https:\/\/lumomat.fr\/wp-content\/uploads\/2025\/11\/Soutenance-These-Teodora-Lupoi@72x.webp 1081w\" sizes=\"(max-width: 820px) 100vw, 820px\" \/><\/figure>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>This thesis is supervised by Dr. Florence Geneste \u2013 CNRS \/ Rennes University \/ ISCR and Dr. Cecilia Cristea \u2013 UMF \u201cIuliu Hatieganu\u201d Cluj Napoca <br>Examining Committee : <br>\u2796 Dr. Elisabeth Lojou \u2013 CNRS \/ Aix Marseille University \u2013 Reviewer <br>\u2796 Prof. Charles Henry \u2013 Colorado State University \u2013 Reviewer <br>\u2796 Prof. Daniela-Luiza Baconi \u2013 UMF \u201cIuliu Hatieganu\u201d Bucharest \u2013 Examiner <br>\u2796 Prof. Radu Nicolae Oprean \u2013 UMF \u201cIuliu Hatieganu\u201d Cluj Napoca \u2013 Examiner <br>\u2796 Dr. Yann Leroux \u2013 CNRS \/ Rennes University \u2013 Invited Member <br>\u2796 Prof. Bela Kiss \u2013 UMF \u201cIuliu Hatieganu\u201d Cluj Napoca \u2013 Invited Member<\/p>\n\n\n\n<p>This thesis is supported by the University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d<\/p>\n\n\n\n<p><strong>\ud83d\udcc4 Abstract:<\/strong> This thesis focuses on the development of new electrochemical sensors for the detection of two analytes: erythromycin (ERY) and diclofenac (DCF). In the first approach, detection relied on the integration of recognition elements based on single-stranded DNA molecules, known as aptamers. An aptamer specific to ERY was immobilized via self-assembled monolayer (SAM) formation on a gold substrate. The surface functionalization protocol was thoroughly optimized to ensure stable baseline signals and avoid false positives. In a more unconventional approach, a DCF-specific aptamer was immobilized on a carbon electrode through click chemistry. The electrode surface was pre-functionalized by electrochemical reduction of the protected diazonium salts. The same strategy was then adapted to a graphene field-effect transistor (GFET), yielding an electronic sensor with improved analytical performance. Finally, a photolithographed ultramicroelectrode array was developed and coupled with the sampled-current voltammetry (SCV) technique. The array was characterized by both optical and electrochemical methods. Coupling with SCV led to lower limits of detection and higher sensitivity compared to its macroelectrode counterpart. Moreover, this approach enabled efficient direct detection of DCF, mitigating the electrode passivation typically associated with its electrochemical oxidation.<\/p>\n\n\n\n<hr class=\"wp-block-separator has-alpha-channel-opacity\"\/>\n\n\n\n<p>\ud83c\udf93 <strong>Soutenance de Th\u00e8se &#8211; <\/strong>Teodora Lupoi soutiendra sa th\u00e8se intitul\u00e9e : conception et d\u00e9veloppement de plateformes nanostructur\u00e9es pour capteurs \u00e9lectrochimiques destin\u00e9s \u00e0 la d\u00e9tection des contaminants pharmaceutiques dans l\u2019environnement <br>\ud83d\udcc5 Mercredi 10 D\u00e9cembre 2025 \u00e0 9h \u00e0 l\u2019Universit\u00e9 de M\u00e9decine et de Pharmacie \u201cIuliu Hatieganu\u201d \u00e0 Cluj-Napoca \u2013 Roumanie<\/p>\n\n\n\n<p>Cette th\u00e8se est dirig\u00e9e par Dr. Florence Geneste \u2013 CNRS \/ Rennes University \/ ISCR et par Dr. Cecilia Cristea \u2013 UMF \u201cIuliu Hatieganu\u201d Cluj Napoca <br>Jury : <br>\u2796 Dr. Elisabeth Lojou \u2013 CNRS \/ Aix Marseille University \u2013 Raporteur <br>\u2796 Prof. Charles Henry \u2013 Colorado State University \u2013 Raporteur <br>\u2796 Prof. Daniela-Luiza Baconi \u2013 UMF \u201cIuliu Hatieganu\u201d Bucharest \u2013 Examinatrice <br>\u2796 Prof. Radu Nicolae Oprean \u2013 UMF \u201cIuliu Hatieganu\u201d Cluj Napoca \u2013 Examinateur <br>\u2796 Dr. Yann Leroux \u2013 CNRS \/ Rennes University \u2013 Membre invit\u00e9 <br>\u2796 Prof. Bela Kiss \u2013 UMF \u201cIuliu Hatieganu\u201d Cluj Napoca \u2013 Membre invit\u00e9<\/p>\n\n\n\n<p>Cette th\u00e8se est soutenue par l\u2019Universit\u00e9 de M\u00e9decine et de Pharmacie \u201cIuliu Hatieganu\u201d<\/p>","protected":false},"excerpt":{"rendered":"<p>\ud83c\udf93 Thesis Defense &#8211; Teodora Lupoi will defend her PhD thesis: development of nanostructured platforms for electrochemical sensors for the detection of environmental pharmaceutical pollutants \ud83d\udcc5 Wednesday December 10th 2025 at 9:00 at the University of Medicine and Pharmacy \u201cIuliu Hatieganu\u201d in Cluj-Napoca \u2013 Romania This thesis is supervised by Dr. Florence Geneste \u2013 CNRS [&hellip;]<\/p>\n","protected":false},"author":7,"featured_media":8995,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"inline_featured_image":false,"site-sidebar-layout":"default","site-content-layout":"","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"set","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"","background-image":"","background-repeat":"repeat","background-position":"center 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